Abstract

Potentiating of cholinergic activity which increases the acetylcholine level in the brain has been regarded as an approach for the palliative treatment of alzheimer's disease. Accordingly, inhibition of the acetyl cholinesterase enzyme is considered to be a viable and attractive I therapeutic strategy for alzheimer's disease patients. In an attempt to find a new acetyl cholinesterase inhibitor (AChEI), 1-benzylpiperidin-4-yl-ethylamine has been reacted with thiophen-3-carbonylchloride to prepare 1-benzyl-4-2-(3-thienylcarbonyl-amino)ethylpiperidine, as potential acetyl cholinesterase inhibitor. The structure of target compound was confirmed by mass, NMR and IR spectra.