(2021) Cumulative Evidence for Association of IL-10-1082G > A Polymorphism with Susceptibility to Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis. Fetal and Pediatric Pathology. pp. 471-485. ISSN 1551-3815
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Abstract
Background: The IL-10 -1082 G > A polymorphism has been reported to be associated with a risk of recurrent pregnancy loss (RPL) with inconsistent results. Thus, to clarify the effect of the polymorphism on the susceptibility to RPL, a meta-analysis was performed. Methods: A systematic literature search in PubMed, Web of Science, Scopus and SciELO was performed to identify the relevant studies published up to December 20, 2019, and related information was extracted. Results: A total of 17 case-control studies with 3,224 RPL cases and 3,295 controls were selected. Pooled data revealed that IL-10 -1082 G > A polymorphism was significantly associated with risk of RPL in the global population. Moreover, subgroup analysis indicated a significant association in Caucasians, but not in Asian or mixed populations. Conclusions: Our pooled data highlights that IL-10 -1082 G > A polymorphism is a risk factor for RPL susceptibility in the global population, especially in Caucasians.
| Item Type: | Article |
|---|---|
| Keywords: | Recurrent miscarriage interleukin 10 polymorphism association cytokine gene polymorphisms loss risk promoter polymorphisms il-10 women Pathology Pediatrics |
| Page Range: | pp. 471-485 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Journal Index: | WoS |
| Volume: | 40 |
| Number: | 5 |
| Identification Number: | https://doi.org/10.1080/15513815.2020.1716903 |
| ISSN: | 1551-3815 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/30182 |
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