Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Association of <i>Epidermal Growth Factor</i> 61A&gt;G, Survivin-31G&gt;C, and EFNA1-1732G&gt;A Polymorphisms with Susceptibility to Colorectal Cancer

(2022) Association of <i>Epidermal Growth Factor</i> 61A&gt;G, Survivin-31G&gt;C, and EFNA1-1732G&gt;A Polymorphisms with Susceptibility to Colorectal Cancer. Journal of Gastrointestinal Cancer. pp. 78-83. ISSN 1941-6628

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Abstract

Background Genetic polymorphisms play an important role in the development of colorectal cancer (CRC). Functional variants in the epidermal growth factor (EGF), survivin, and Ephrin A1 (EFNA1) genes have been previously reported to play a potential role in susceptibility to CRC, but these polymorphisms have not been well replicated. The aim of this study was to assess the association of the EGF 61A>G, Survivin -31G>C, and EFNA1 -1732G>A polymorphisms with the susceptibility to CRC in an Iranian population. Methods A total of 148 cases diagnosed with CRC and 160 healthy subjects were recruited. The EGF 61A>G, survivin -31G>C, and EFNA1 -1732G>A polymorphisms were genotyped using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. Results Our data revealed that the homozygous mutant genotype (CC: OR = 2.895, 95 CI = 1.092-7.673, p = 0.033) and mutant allele (C: OR = 1.629, 95 CI = 1.152-2.303, p = 0.006) of the survivin -31G>C were associated with an increased risk of CRC in the Iranian population. However, our results failed to show an association between the EGF 61A>G and EFNA1 -1732G>A polymorphisms and CRC risk. Conclusion Our results revealed that the survivin -31G>C polymorphism might play an important role in development of CRC in Iranian population. However, no association of EGF 61A>G and EFNA1 -1732G>A polymorphisms with CRC risk was found.

Item Type: Article
Keywords: Colorectal cancer Epidermal growth factor Survivin Ephrin A1 Polymorphism Association promoter gene polymorphism cervical-cancer risk survivin efna1 Oncology Gastroenterology & Hepatology
Page Range: pp. 78-83
Journal or Publication Title: Journal of Gastrointestinal Cancer
Journal Index: WoS
Volume: 53
Number: 1
Identification Number: https://doi.org/10.1007/s12029-020-00551-4
ISSN: 1941-6628
Depositing User: Mr mahdi sharifi
URI: http://eprints.ssu.ac.ir/id/eprint/30178

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