Abstract

Background: Due to the importance of choosing the applicable dosimetry method in radionuclide therapy, the present study was conducted to investigate the efficiency of the implementation of Dose Point Kernel (DPK) for dose optimization of Lu-177/Y-90 Cocktail Radionuclides in internal Dosimetry. Methods: In this study, simulations and calculations of DPK were performed using the GATE/GEANT4 Monte Carlo code. For specific liver dosimetry, the NCAT phantom and convolution algorithm-based Fast Fourier Transform method was used by MATLAB software. Results: The self-dose of Lu-177 and Y-90 radionuclides in the liver of NCAT phantom were 1.1708E-13, and 4.8420E-11 (Gy/Bq), respectively, and the cross-dose of Lu-177 and Y-90 radionuclides out of the liver of NCAT phantom were 2.03615E-16, and 0.8422E-13 (Gy/Bq) respectively. Overall results showed that with an increase the value of Y-90 with quarter steps in a cocktail, the amount of the self-dose increase 1.5, 6, and 29 times respectively, and with an increase the value of Lu-177 in quarter step in a cocktail, the amount of the cross dose decrease 3, 15 and 68 percent respectively. Conclusion: Generally, the present results indicate that the calculated DPK functions of Lu-177 and Y-90 cocktails can play an important role in choosing the best combination of radionuclide to optimize treatment planning in cocktail radionuclide therapy.