Abstract

In this research, cadmium oxide nanoparticles (CdO Nps) were synthesized from Salvia officinalis and their anti-fungal biofilm effects were evaluated in single form and also in combination with fluconazole. The physicochemical properties of the synthesized CdO Nps were investigated by using Scanning Electron Microscopy (SEM), double beam ultraviolet-visible spectrophotometer (UV-Vis), energy-dispersive X-ray spectroscopy (EDX) and Particle Size Analyzer (PSA). Results of this research showed that found CdO Nps possesses quantum effects and their size is in the range of 10-70 nm. These nanoparticles have good anti-fungal biofilm properties (P (value) <= 0/05) compared to fluconazole antibiotic (P (value) = 0.00) and control group. Synthesized CdO Nps reduced 80.86 of the biofilm and 31.92 of the fluconazole antibiotic compared to control group. The mixture of these nanoparticles and fluconazole has desirable anti fungal biofilm effects and in fact it reduced 91.49 of the biofilm, compared to the single concentration and control group. Time-kill study of combined concentration showed a significant reduction in the number of yeast cells at the level of (P <= 0/05).