(2019) Correlation between interleukin-28 gene polymorphism with interleukin-28 cytokine levels and viral genotypes among HCV patients in Yazd, Iran. BMC Research Notes. p. 5.
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Abstract
Objectives Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. Result The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003).
| Item Type: | Article |
|---|---|
| Keywords: | Polymorphism Hepatitis C IL-28B genotype Yazd Life Sciences & Biomedicine - Other Topics Science & Technology - Other Topics |
| Page Range: | p. 5 |
| Journal or Publication Title: | BMC Research Notes |
| Journal Index: | WoS |
| Volume: | 12 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1186/s13104-019-4651-z |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/29817 |
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