(2018) Serum Levels of IL-6, IL-8, TNF-α, and TGF-β in Chronic HBV-Infected Patients: Effect of Depression and Anxiety. Laboratory Medicine. pp. 41-46. ISSN 0007-5027
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Abstract
Objective: To assess the effects of depression and anxiety on serum cytokine levels in patients with chronic hepatitis B (CHB) infection. Methods: In this cross-sectional study, 60 healthy control individuals and 60 patients with CHB participated after filling out standard questionnaires. We examined their serum interleukin (IL)-6, IL-8, tumor necrosis factor (TNF)-alpha, and TGF-beta levels using enzyme-linked immunosorbent assay (ELISA) techniques. Results: In patients with CHB compared with healthy controls, serum levels of IL-8 were significantly increased, whereas IL-6 and TGF-beta levels were significantly decreased. Serum levels of TGF-beta were significantly decreased in the patients with CHB who had mild depression, compared with patients with CHB without depression and with moderate and severe depression. Conclusions: Downregulation of IL-8 and TGF-beta, respectively, is a corresponding mechanism for induction of chronic inflammation in patients with CHB. Depression also seems to induce inflammation via downregulation of TGF-beta in these patients.
| Item Type: | Article |
|---|---|
| Keywords: | psychiatric diseases chronic HBV infection IL-6 IL-8 TGF-beta TNF-alpha chronic hepatitis-b profile Medical Laboratory Technology |
| Page Range: | pp. 41-46 |
| Journal or Publication Title: | Laboratory Medicine |
| Journal Index: | WoS |
| Volume: | 49 |
| Number: | 1 |
| Identification Number: | https://doi.org/10.1093/labmed/lmx064 |
| ISSN: | 0007-5027 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/29798 |
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