Abstract

Background: We investigated the possibility of an association between the C-2383T polymorphism (rs3761549) in the promoter region of the FOXP3 gene with breast cancer. Methods: The study groups consisted of 250 women diagnosed with breast cancer (case group) and 250 healthy women (control group). Polymerase chain reaction-restriction fragment length polymorphism was performed for genotyping. Results: Breast cancer cases had a C allele frequency of 455 (91) and T allele frequency of 45 (9). The control group had a C allele frequency of 468 (93.6) and 32 (6.4) for the T allele. The CC genotype was present in 206 (82.4) patients, 43 (17.2) patients had the CT genotype, and the TT genotype was observed in 1 (0.4) patient. In the control group, 219 (87.6) had the CC genotype, whereas 30 (12) had the CT genotype, and 1 (0.4) had the TT genotype. Statistical analysis revealed no significant differences in the distribution of alleles and genotypes between patients and controls (P>0.05). There was no significant association between genotype distribution and patients' clinicopathological factors. Conclusion: Our results do not support an association between the FOXP3 -2383 C/T polymorphism and breast cancer in a population from southern Iran.