(2015) Synthesis and Evaluation of Chroman-4-One Linked to <i>N</i>-Benzyl Pyridinium Derivatives as New Acetylcholinesterase Inhibitors. Archiv der Pharmazie. pp. 643-649. ISSN 0365-6233
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Abstract
A novel series of chroman-4-one derivatives containing the N-benzyl pyridinium moiety were designed, synthesized, and evaluated for their acetylcholinesterase (AChE) inhibitory activities. Among the various synthesized compounds, (E)-1-(2,3-dibromobenzyl)-4-((7-ethoxy-4-oxochroman-3-ylidene)methyl)pyridinium bromide (8l) depicted the most potent anti-AChE activity (IC50=0.048M). In addition, the molecular modeling study allowed us to detect possible binding modes that are in full compliance with the observed results through in vitro experiments.
| Item Type: | Article |
|---|---|
| Keywords: | Acetylcholinesterase Alzheimer's disease Chroman-4-one Docking study N-Benzyl pyridinium beta-amyloid aggregation alzheimers-disease anticholinesterase activity binding design cholinesterases docking potent Pharmacology & Pharmacy Chemistry |
| Page Range: | pp. 643-649 |
| Journal or Publication Title: | Archiv der Pharmazie |
| Journal Index: | WoS |
| Volume: | 348 |
| Number: | 9 |
| Identification Number: | https://doi.org/10.1002/ardp.201500149 |
| ISSN: | 0365-6233 |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/29669 |
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