(2019) Association of rs2234693 and rs9340799 polymorphisms of estrogen Receptor-1 gene with radiographic defined knee osteoarthritis: A meta-analysis. Journal of Orthopaedics. pp. 234-240. ISSN 0972-978X
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Abstract
Objective: To evaluate the association of ESR1 rs2234693 and rs9340799 polymorphisms with radiographic defined knee osteoarthritis (OA), a case-control and meta-analysis was performed. Methods: A total of 25 case-control studies with 7,144 cases and 8,468 controls with were included. Results: There was a significant association between rs2234693 polymorphism and radiographic knee OA under heterozygote model (CT vs. TT: OR = 1.164, 95 CI 1.053-1.286, p = 0.003). However, there was no association between rs9340799 and radiographic knee OA. In subgroup analysis by ethnicity, risk estimates were not augmented. Conclusions: Our results showed that the ESR1 rs2234693 polymorphism might be associated with radiographic defined knee OA, but not rs9340799.
| Item Type: | Article |
|---|---|
| Keywords: | Osteoarthritis Knee Radiographic ESR1 gene Meta-analysis g-greater-than alpha gene susceptibility haplotype population Orthopedics |
| Page Range: | pp. 234-240 |
| Journal or Publication Title: | Journal of Orthopaedics |
| Journal Index: | WoS |
| Volume: | 16 |
| Number: | 3 |
| Identification Number: | https://doi.org/10.1016/j.jor.2019.02.022 |
| ISSN: | 0972-978X |
| Depositing User: | Mr mahdi sharifi |
| URI: | http://eprints.ssu.ac.ir/id/eprint/28962 |
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