(2022) Carboxylated Graphene Oxide as a Nanocarrier for Drug Delivery of Quercetin as an Effective Anticancer Agent. Iranian Biomedical Journal. pp. 324-329.
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Abstract
Background: Enhancing the therapeutic profile of hydrophobic drugs using the development of biocompatible drug delivery systems is an urgent need. Many types of research have been conducted on graphene derivatives owing to their unique characteristics. Methods: In this survey, QUER, a natural medicine, was loaded on carboxylated GO, and cytotoxicity assay and the uptake of QUER into prostate cancer cells (PC3) were evaluated. Results: The release behavior of QUER was temperature-and pH-sensitive. Although QUER was loaded with high efficiency, the released rate was low (23.25 at pH 5.5 and 42 °C). The toxicity and intensity of fluorescence in the FREE QUER were higher than the loaded form. Conclusion: High-capacity loading and controlled release of GO QUER can be recognized as a proper candidate in treating cancer. © 2022, Pasteur Institute of Iran. All rights reserved.
| Item Type: | Article |
|---|---|
| Keywords: | antineoplastic agent; graphene oxide; nanocarrier; quercetin; antineoplastic agent; graphene oxide; graphite; quercetin, Article; cancer cell line; controlled release formulation; controlled study; cytotoxicity assay; drug cytotoxicity; drug delivery system; drug effect; drug efficacy; drug release; drug tumor level; fluorescence intensity; human; human cell; PC3 cell line; pH; prostate cancer; temperature sensitivity; chemistry; drug delivery system; male, Antineoplastic Agents; Drug Delivery Systems; Graphite; Humans; Male; Quercetin |
| Page Range: | pp. 324-329 |
| Journal or Publication Title: | Iranian Biomedical Journal |
| Volume: | 26 |
| Number: | 4 |
| Publisher: | Pasteur Institute of Iran |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/13138 |
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