Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Glutaraldehyde crosslinked doxorubicin promotes drug delivery efficiency using cobalt ferrite nanoparticles

(2022) Glutaraldehyde crosslinked doxorubicin promotes drug delivery efficiency using cobalt ferrite nanoparticles. Colloids and Surfaces B: Biointerfaces.

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Doxorubicin (DOX) is a common chemotherapy agent that is used in clinics for the treatment of a wide spectrum of cancers. Herein, a novel approach for improving doxorubicin loading on nanoparticles and also controlled release is suggested using crosslinking doxorubicin molecules with glutaraldehyde. We investigated the loading efficiency of doxorubicin on CoFe2O4 nanoparticles in the absence and presence of glutaraldehyde. Based on the feasible, one-pot, and time-saving approach suggested here, the crosslinked DOX showed loading efficiency about twice more in comparison with the non-crosslinked DOX. In vitro doxorubicin release of three formulations including DOX crosslinked with glutaraldehyde (DOXGA), DOX loaded on CoFe2O4 (CFDOX) and DOX loaded on CoFe2O4 using glutaraldehyde (CFDOXGA) yielded a sustained release. The kinetic models such as first-order, Sahlin-Peppas, and Higuchi were employed for further exploration of DOX release profile. Our suggested method might extend to other nanomaterial-based drug delivery formulations to promote drug delivery efficiency. © 2022 Elsevier B.V.

Item Type: Article
Keywords: Chemotherapy; Cobalt; Controlled drug delivery; Drug products; Efficiency; Ferrite; Iron compounds; Loading; Targeted drug delivery, Chemotherapy agents; Cobalt ferrite nanoparticles; Cofe2O4 spinel ferrite; Crosslinked; Doxorubicin; Drug release; Glutaraldehydes; Loading efficiency; Spinel ferrites; Wide spectrum, Nanoparticles, cobalt ferrite; doxorubicin; drug carrier; glutaraldehyde; nanoparticle, drug delivery system; drug release, Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glutaral; Nanoparticles
Journal or Publication Title: Colloids and Surfaces B: Biointerfaces
Volume: 220
Publisher: Elsevier B.V.
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/13124

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