(2022) Glutaraldehyde crosslinked doxorubicin promotes drug delivery efficiency using cobalt ferrite nanoparticles. Colloids and Surfaces B: Biointerfaces.
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Abstract
Doxorubicin (DOX) is a common chemotherapy agent that is used in clinics for the treatment of a wide spectrum of cancers. Herein, a novel approach for improving doxorubicin loading on nanoparticles and also controlled release is suggested using crosslinking doxorubicin molecules with glutaraldehyde. We investigated the loading efficiency of doxorubicin on CoFe2O4 nanoparticles in the absence and presence of glutaraldehyde. Based on the feasible, one-pot, and time-saving approach suggested here, the crosslinked DOX showed loading efficiency about twice more in comparison with the non-crosslinked DOX. In vitro doxorubicin release of three formulations including DOX crosslinked with glutaraldehyde (DOXGA), DOX loaded on CoFe2O4 (CFDOX) and DOX loaded on CoFe2O4 using glutaraldehyde (CFDOXGA) yielded a sustained release. The kinetic models such as first-order, Sahlin-Peppas, and Higuchi were employed for further exploration of DOX release profile. Our suggested method might extend to other nanomaterial-based drug delivery formulations to promote drug delivery efficiency. © 2022 Elsevier B.V.
Item Type: | Article |
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Keywords: | Chemotherapy; Cobalt; Controlled drug delivery; Drug products; Efficiency; Ferrite; Iron compounds; Loading; Targeted drug delivery, Chemotherapy agents; Cobalt ferrite nanoparticles; Cofe2O4 spinel ferrite; Crosslinked; Doxorubicin; Drug release; Glutaraldehydes; Loading efficiency; Spinel ferrites; Wide spectrum, Nanoparticles, cobalt ferrite; doxorubicin; drug carrier; glutaraldehyde; nanoparticle, drug delivery system; drug release, Doxorubicin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Glutaral; Nanoparticles |
Journal or Publication Title: | Colloids and Surfaces B: Biointerfaces |
Volume: | 220 |
Publisher: | Elsevier B.V. |
Depositing User: | ms soheila Bazm |
URI: | http://eprints.ssu.ac.ir/id/eprint/13124 |
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