(2022) Association of Fetal MTHFR C677T Polymorphism with Susceptibility to Neural Tube Defects: A Systematic Review and Update Meta-Analysis. Fetal and Pediatric Pathology. pp. 225-241.
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Abstract
Background MTHFR gene may be a key epigenetic regulation-related factor crucial during embryogenesis. We performed a meta-analysis to determine the association of fetal MTHFR C677T polymorphism with neural tube defects (NTDs). Methods A comprehensive literature search of the PubMed, Embase, and CNKI database was performed up to April 10, 2020. Results A total of 19 case-control studies with 2,228 NTDs cases and 4,220 controls were identified. Pooled data revealed that the fetal MTHFR C677T polymorphism was significantly highly correlated with development of NTDs in the overall population. Stratified analysis showed a significant association among Caucasians and Asians, but not in mixed populations. There was a significant association between the MTHFR C677T polymorphism and spina bifida risk. No publication bias was found under any genetic model. Conclusions Our pooled data support the fetal MTHFR C677T polymorphism association with risk of NTDs, especially among Caucasians and Asians. © 2020 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | methylenetetrahydrofolate reductase (NADPH2); methylenetetrahydrofolate reductase (NADPH2); MTHFR protein, human, Asian; Caucasian; CNKI database; data extraction; DNA polymorphism; Embase; encephalocele; gene frequency; genetic association; genetic model; genetic susceptibility; genotyping; human; Medline; meningomyelocele; meta analysis; polymerase chain reaction restriction fragment length polymorphism; Review; sample size; sensitivity analysis; systematic review; case control study; female; genetic epigenesis; genetic predisposition; genetics; neural tube defect; single nucleotide polymorphism, Case-Control Studies; Epigenesis, Genetic; Female; Genetic Predisposition to Disease; Humans; Methylenetetrahydrofolate Reductase (NADPH2); Neural Tube Defects; Polymorphism, Single Nucleotide |
| Page Range: | pp. 225-241 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Volume: | 41 |
| Number: | 2 |
| Publisher: | Taylor and Francis Ltd. |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/13082 |
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