Abstract

Background: Flaxseed has rich content of alpha linolenic acid for preventing pro inflammatory process. The aim of present study is exploring the effect of flaxseed oil supplementation on inflammatory biomarkers and body composition in overweight adults with pre-diabetes. Material and methods: this double-blind randomized clinical trial conducted with 80 overweight pre-diabetic patients in 2 clusters (flaxseed oil group (2000-mg daily) and control group) across a 14-week period. Anthropometric indices, body composition and inflammatory indices were measured between 2 groups before and after the treatment. Result: this study found a significant decrease in visceral fat level in the intervention group (P =.009) and control group (P =.004) at the end of the survey. However, the mean change of it (P =.06) was not significant. Also, this study showed that percentage of body fat (P =.31) and its mean change (P =.6) did not have significantly different between the 2 groups at the 14th week. The skeletal muscle had a significant rise in the intervention group (P =.005) and control group (P =.003) by the end of 14th week. However, the mean change of it (P =.19) was not significant between the 2 groups. In addition, there was no significant change in the fasting blood glucose (P =. 7), C reactive protein (P =.12) and TNF-α (P =.22) between the 2 groups at the end of study. Conclusion: It showed that flaxseed oil supplementation cannot improve body composition and inflammation. © The Author(s) 2022.