Repository of Research and Investigative Information

Repository of Research and Investigative Information

Shahid Sadoughi University of Medical Sciences

Male factor testing in recurrent pregnancy loss cases: A narrative review

(2022) Male factor testing in recurrent pregnancy loss cases: A narrative review. International Journal of Reproductive BioMedicine. pp. 447-460.

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Abstract

Recurrent pregnancy loss is a distinct disorder defined as the loss of at least 2 pregnancies before the 20th wk of gestation. With half of the genome of the embryo belonging to the father, the integrity of the sperm genome is crucial for a successful pregnancy. Semen analysis is recommended for men in such cases to evaluate sperm concentration, morphology, vitality and motility. However, other important sperm parameters such as sperm epigenetics, aneuploidy, Y chromosome microdeletion and chromatin integrity also correlate with successful pregnancy and delivery rate. This article examines the use of different sperm tests and their importance in male partners of women suffering from recurrent pregnancy loss. © 2022, Research and Clinical Center for Infertitlity. All rights reserved.

Item Type: Article
Keywords: aneuploidy; chromatin; comet assay; DNA damage; DNA fragmentation; epigenetics; female; gene deletion; human; male; obstetric delivery; pregnancy; recurrent abortion; Review; semen analysis; semen parameters; sperm; sperm viability; spermatozoon density; spermatozoon motility; TUNEL assay; Y chromosome
Page Range: pp. 447-460
Journal or Publication Title: International Journal of Reproductive BioMedicine
Volume: 20
Number: 6
Publisher: Research and Clinical Center for Infertitlity
Depositing User: ms soheila Bazm
URI: http://eprints.ssu.ac.ir/id/eprint/12908

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