(2022) Association of PAI-1 4G/5G and ACE I/D Polymorphisms with Susceptibility to Pediatric Sepsis: Evidence from a Meta-Analysis. Fetal and Pediatric Pathology. pp. 242-258.
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Abstract
Background Several studies have investigated the role of PAI-1 4G/5G and ACE I/D polymorphisms in the etiology of pediatric sepsis, but the results are inconsistent. We performed a meta-analysis to assess for any associations. Methods: A comprehensive literature search on PubMed, web of science, and CNKI database was conducted up to April 15, 2020. Results: There were twelve case-control studies involving seven studies with 860 cases and 1144 controls on PA-1 4G/5G and five studies with 1602 cases and 1585 controls on ACE I/D. PAI-1 4G/5G and ACE I/D polymorphisms were associated with an increased risk of pediatric sepsis in the global population. Stratified analysis by ethnicity showed a significant association in the Caucasians children. Conclusions: The meta-analysis suggests that the PAI-1 4G/5G and ACE I/D polymorphisms may be risk factors for development of pediatric sepsis in the global population. © 2020 Taylor & Francis Group, LLC.
| Item Type: | Article |
|---|---|
| Keywords: | dipeptidyl carboxypeptidase; plasminogen activator inhibitor 1; plasminogen activator inhibitor 1, Caucasian; child; Chinese Biomedical database; CNKI database; Cochrane Library; data extraction; Embase; ethnicity; female; genetic association; genetic susceptibility; human; male; Medline; meta analysis; publication bias; Review; risk factor; school child; sepsis; septicemia; single nucleotide polymorphism; systematic review; systemic inflammatory response syndrome; WanFang Database; Web of Science; case control study; genetic polymorphism; genetic predisposition; genetics; genotype, Case-Control Studies; Child; Genetic Predisposition to Disease; Genotype; Humans; Plasminogen Activator Inhibitor 1; Polymorphism, Genetic; Risk Factors; Sepsis |
| Page Range: | pp. 242-258 |
| Journal or Publication Title: | Fetal and Pediatric Pathology |
| Volume: | 41 |
| Number: | 2 |
| Publisher: | Taylor and Francis Ltd. |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/12663 |
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