Abstract

Henna plant (Lawsonia inermis L.) has unique properties and has long been used as a herbal remedy. In this study, polyvinyl alcohol (PVA) nanofibers containing henna extract in two different concentrations were studied to prepare a wound dressing using electrospinning. PVA polymer nanofibers using henna extract with two different concentrations of 3 and 6 were prepared by the electrospinning method. Human fibroblasts were cultured on these fibers and the mechanical and survival properties of the cells, as well as the antibacterial properties of henna were compared and evaluated. The results showed that by using of henna extract in PVA nanofibers, cell viability was significantly reduced (P�0.05). However, the ability of nanofibers to water uptake and mechanical properties of fibers significantly increased with increasing concentrations of henna extract (P�0.05). Nanofiber wound dressing with antibacterial properties of henna extract provides relatively fast and rapid wound healing. The resulting fibers are encouraging candidates for the development of improved bandaging materials. Copyright © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.