Abstract

In this study, a novel polycaprolactone/gelatin/polydimethylsiloxane (PCL/G/PDMS) scaffold with improved mechanical properties and controllable porous structure was prepared through electrospinning method. In this research, the biocompatibility was evaluated, using mouse uterine cells. MTT, Hematoxylin-Eosin (H&E) staining results indicated that the growth of endometrial cells developed in the PCL/G/PDMS scaffold. The results also showed that the mouse embryo good adaptation with the scaffold and the scaffold transplantation to the mouse uterus showed that the uterine tissue was completely perfused after one month. Our data suggests that the PCL/G/PDMS scaffold is a new suitable scaffold material for tissue engineering. The purpose of this project is to eliminate of problems similar to damaged uterus, Rennet uterus (surrogacy), Lack of womb for women's using a scaffold like uterine tissue. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.