(2022) The role of miR-153 and related upstream/downstream pathways in cancers: from a potential biomarker to treatment of tumor resistance and a therapeutic target. Medical Oncology.
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Abstract
MicroRNAs (miRNAs/miRs) are small non-coding RNAs that have a multifunction and play essential roles in gene regulation. Their dysregulation is associated with several human cancers. MiR-153 has a critical role in many biological processes, such as suppressing tumor growth (mostly), responses to treatment, and drug resistance. However, miR-153 in some cancers shows a different role as an oncogene, such as prostate. The miR-153 expression can be regulated by several regulators, such as lncRNAs and circular RNAs. By discovering the target factors for miR-153, it may be possible to approach early diagnosis, reversing drug resistance, and treatment of cancers. This will help choose the precise treatment for the patient and not incur additional costs in treatment. Thus, we attempt to summarize the current situation and potential development prospects about the role of miR-153 in cancers. Graphical abstract: The miR-153 paly an important role in cancers and can be used for diagnosis and prognosis. Figure not available: see fulltext. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
| Item Type: | Article |
|---|---|
| Keywords: | antineoplastic agent; circular ribonucleic acid; long untranslated RNA; microRNA; microRNA 153; tumor marker; unclassified drug; long untranslated RNA; microRNA; MIRN153 microRNA, human; tumor marker, cancer resistance; cancer therapy; colorectal cancer; drug cost; early cancer diagnosis; esophageal squamous cell carcinoma; gene control; glioblastoma; glioma; human; larynx squamous cell carcinoma; lymphatic leukemia; malignant neoplasm; melanoma; mouth squamous cell carcinoma; non small cell lung cancer; osteosarcoma; pancreas cancer; pathophysiology; protein expression; Review; triple negative breast cancer; genetics; male; metabolism; neoplasm; prognosis, Biomarkers, Tumor; Humans; Male; MicroRNAs; Neoplasms; Prognosis; RNA, Long Noncoding |
| Journal or Publication Title: | Medical Oncology |
| Volume: | 39 |
| Number: | 5 |
| Publisher: | Springer |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/12301 |
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