(2021) Age-Specific Differences in the Severity of COVID-19 Between Children and Adults: Reality and Reasons. Advances in Experimental Medicine and Biology. pp. 63-78.
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Abstract
In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections, children experience mild symptoms compared to adults. However, the precise explanations for this disparity are not clear. Thus, we attempted to identify rational explanations about age-related differences as reported in different studies. Given the incomplete data on SARS-CoV-2, some information has been gathered from other studies of earlier coronavirus or influenza outbreaks. Age-related differences in disease severity are important with regard to diagnosis, prognosis, and treatment of SARS-CoV-2 infections. In addition, these differences impact social distancing needs, since pediatric patients with mild or asymptomatic are likely to play a significant role in disease transmission. © 2021, The Author(s), under exclusive license to Springer Nature Switzerland AG.
| Item Type: | Article |
|---|---|
| Keywords: | BCG vaccine; gamma interferon; hemoglobin; lactoferrin; sex hormone, adaptive immunity; adult; child; clinical feature; coronavirus disease 2019; cross protection; disease severity; efferocytosis; groups by age; hormone action; human; immune system; immunocompetent cell; innate immune cell; molecularly targeted therapy; neutrophil lymphocyte ratio; nonhuman; outdoor activity; physical activity; protein function; Severe acute respiratory syndrome coronavirus 2; virus transmission; age; epidemic; influenza, Adult; Age Factors; Child; COVID-19; Disease Outbreaks; Humans; Influenza, Human; SARS-CoV-2 |
| Page Range: | pp. 63-78 |
| Journal or Publication Title: | Advances in Experimental Medicine and Biology |
| Volume: | 1327 |
| Publisher: | Springer |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/12217 |
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