(2021) The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort. Future Oncology. pp. 4895-4905.
Full text not available from this repository.
Abstract
Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95 CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population. © 2021 Future Medicine Ltd.
| Item Type: | Article |
|---|---|
| Keywords: | immunoglobulin enhancer binding protein, adult; Article; breast carcinoma; cancer risk; cohort analysis; controlled study; DNA polymorphism; female; gene amplification; gene deletion; gene frequency; gene insertion; genetic association; genetic association study; genetic risk; genetic susceptibility; genetic variation; genotype; genotyping technique; human; human tissue; Iran; Iranian (citizen); major clinical study; middle aged; NFKB1 gene; recessive inheritance; retrospective study |
| Page Range: | pp. 4895-4905 |
| Journal or Publication Title: | Future Oncology |
| Volume: | 17 |
| Number: | 35 |
| Depositing User: | ms soheila Bazm |
| URI: | http://eprints.ssu.ac.ir/id/eprint/11589 |
Actions (login required)
 |
View Item |