Abstract

Background Artificial neural networks (ANNs) and adaptive neural-fuzzy Inference system (ANFIS) are the best solutions to finding the correlation between some water parameters and human hormones. The correlation between thyroid stimulating hormone (TSH) and drinking water fluoride studied by ANN and ANFIS models in Yazd city. Method In this study, eighty people with thyroid gland disorder and 213 healthy people invited. Their thyroid hormones and fluoride drinking water analyzed. Results The result of ANFIS showed R = 0.81 for test and R = 0.85 for train in all cases and controls data. This results were R = 0.73 and R = 0.81 for ANNs respectively. Conclusion This models can be used as an alternative for show correlation between Drinking Water Fluoride and TSH Hormone and R = 0.85 gained from ANFIS was the best.