Abstract

Introduction: Malignant peripheral nerve sheath tumors are rare sarcomas derived from peripheral nerves or their sheaths. Head and neck region involvement in malignant peripheral nerve sheath tumors has been reported in only 15% of cases. Case Presentation:A 45-year-old man presented to us because of left forehead area swelling. Computed tomography scan demonstrated a mass originating from left frontal sinus which was associated with bone destruction and soft tissue invasion. Post-operative histopathologic studies and immunohistochemical analysis of the lesion, confirmed «malignant peripheral nerve sheath tumor» as a diagnosis. Conclusions:This case provides evidence that, although rare, malignant peripheral nerve sheath tumors can occur in frontal sinus. Combination of microscopic and immunohistochemical analysis is required for diagnosis of MPNSTs